There are many disorders of a lack of pigmentation in the skin, with different causations and effects, of which vitiligo is only the best known; this comprehensive text from international experts will enable clinicians to diagnose the full range of these conditions and suggest the most effective management options for their patients. Contents: Basic concepts of melanocyte biology * Approach to hypopigmentation * Historical review of vitiligo * Epidemiology and classification of vitiligo * Pathophysiology of vitiligo * Segmental vitiligo * Childhood versus post-childhood vitiligo * Pharmacological therapy of vitiligo * Surgical treatment of vitiligo * Phototherapy and lasers in the treatment of vitiligo * Emerging treatments for vitiligo * Tuberous sclerosis complex * Oculocutaneous albinism * Hermansky-Pudlak syndrome, Chediak-Chigasi syndrome, and Griscelli syndrome * Piebaldism * Waardenburg syndrome * Alezzandrini syndrome, Margolis syndrome, Cross syndrome, and other rare genetic disorders * Mosaic hypopigmentation * Skin disorders causing post-inflammatory hypopigmentation * Infectious and parasitic causes of hypopigmentation * Melanoma leukoderma * Halo nevi * Drug-induced hypopigmentation * Hypopigmentation from chemical and physical agents * Guttate hypomelanosis and progressive hypomelanosis of the trunk (progressive macular hypomelanosis)